New Drugs: Angiotensin converting enzyme inhibitors

Angioedema, angiotensin converting enzyme inhibitors, and angiotensin receptor blocking drugs.

To the Editor: We read with interest the article on the effects of nabilone on postoperative pain by Pierre Beaulieu.1 While it is unfortunate that his results did not generate firm conclusions, we believe that descriptive subgroup analyses may have yielded some important information regarding the effects of nabilone on postoperative morphine consumption and side-effects. Nineteen of the 41 pat...

Angiotensin converting enzyme inhibitors.

The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected t...

Angiotensin-converting enzyme inhibitors.

ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin II (Ang II) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other vasoactive substances. ACE inhibitors differ in the che...

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin-converting enzyme inhibitors: a new mechanism of action.

BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors are valuable agents for the treatment of hypertension, heart failure, and other cardiovascular and renal diseases. The cardioprotective effects of ACE inhibitors are mediated by blockade of both conversion of angiotensin (Ang) I to Ang II and kinin hydrolysis. Here, we report a novel mechanism that may explain the cardiac antifibrotic ef...